{"id":25066,"date":"2018-11-19T19:50:38","date_gmt":"2018-11-19T19:50:38","guid":{"rendered":"https:\/\/www.zandloperspreadsheets.com\/home\/"},"modified":"2024-11-10T22:12:10","modified_gmt":"2024-11-10T21:12:10","slug":"home","status":"publish","type":"page","link":"https:\/\/stant-biotech.com\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t
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STANT<\/h1>


Developing a STING antagonist<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tScience<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tInvestors<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Science<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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STANT b.v. is developing novel therapeutics modulating the STING pathway with potential for the treatment of autoimmune, inflammatory, cardiovascular, metabolic and neurodegenerative diseases. The STING pathway is the body\u2019s master regulator of immune responses to mislocalized or abnormal DNA. During disease pathology, diverse mechanisms cause DNA to be released and to activate the STING pathway, thereby inducing inflammatory mechanisms as well as cell death and autophagy.<\/p>

Based on new insights identified by S\u00f8ren R. Paludan and Sonia Assil, STANT is advancing proprietary compounds that block the STING pathway with a differentiated mode of action. These inhibitors are designed to block the ongoing, perpetual cycle of inflammation amplified following tissue and organ damage and may be used to treat diseases such as systemic lupus erythematosus (SLE), cardiovascular diseases, amyotrophic lateral sclerosis (ALS), Parkinson and chronic inflammatory diseases such as kidney disease.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Team<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tSonia Assil<\/font>
\n<\/span>Founder and head of biology<\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tSonia is Assistant Professor in immunology at Aarhus University Denmark. Her work as (…)<\/span>
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\n\t\t\t\t\t\t\tHans van Eenennaam<\/font>
\n<\/strong>Founder and CEO<\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tHans is CEO and co-founder of IMMIOS and Chief Scientific Officer at Sairopa. Previously (…)<\/span>\n\nRead more<\/i><\/u><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tAllard Kaptein<\/font>
\n<\/strong>Founder and CSO<\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tAllard is Managing Director of Genase Therapeutics, Chief Strategy Officer and (…)<\/span>
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\n\t\t\t\t\t\t\tLars \u00d8stergaard<\/Font>
\n<\/strong>Founder<\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tLars is clinical professor in infectious diseases at Aarhus University, Denmark, and (…)<\/span>
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\n\t\t\t\t\t\t\tS\u00f8ren R Paludan<\/font>
\n<\/strong>Founder<\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tS\u00f8ren is professor in virology and immunology at Aarhus University Denmark. He is (…)\u00a0<\/span>
\nRead more<\/i><\/u><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tPaul Vink<\/font>
\n<\/strong>Founder and head of molecular pharmacology<\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\tPaul is Executive Director and co-founder of IMMIOS. Paul began his career in the (…)<\/span>
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\n\t\t\t\t\t\t\tJac Wijkmans<\/font>
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\n\t\t\t\t\t\t\tJac is Chief Scientific Officer of Flindr Therapeutics and managing director of Inntrest (…)<\/span>
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Investors<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"bom_rgb\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"FIRST\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Contact<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Please contact us at:<\/span>\u00a0<\/strong><\/p>\nSTANT b.v.<\/strong>
\nPivot Park
\n\nKloosterstraat 9, RE1133
\n\n5349 AB, Oss
\n\nThe Netherlands
\n\ninfo@STANT-biotech.com\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

STANT Developing a STING antagonist Science Team Investors Contact Science STANT b.v. is developing novel therapeutics modulating the STING pathway with potential for the treatment of autoimmune, inflammatory, cardiovascular, metabolic and neurodegenerative diseases. The STING pathway is the body\u2019s master regulator of immune responses to mislocalized or abnormal DNA. During disease pathology, diverse mechanisms cause […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"enabled","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-25066","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/stant-biotech.com\/index.php?rest_route=\/wp\/v2\/pages\/25066","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stant-biotech.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/stant-biotech.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/stant-biotech.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/stant-biotech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25066"}],"version-history":[{"count":600,"href":"https:\/\/stant-biotech.com\/index.php?rest_route=\/wp\/v2\/pages\/25066\/revisions"}],"predecessor-version":[{"id":26332,"href":"https:\/\/stant-biotech.com\/index.php?rest_route=\/wp\/v2\/pages\/25066\/revisions\/26332"}],"wp:attachment":[{"href":"https:\/\/stant-biotech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}